The 2021/22 TotalEnergies CAF Champions League Group Stage draw was conducted at Caf headquarters in Cairo, Egypt on Tuesday 28 December 2021.
Khaled Nassar, Caf Head of Competitions was in charge of the draw assisted by the coach of the 10-time Champions League (Al Ahly SC) winners head coach Pitso Mosimane.
Al Ahly, Sundowns, Al Hilal, Al Merrikh
Raja, Horoya, ES Setif, AmaZulu
Esperance, Etoile, CR Belouizdad, Jwaneng Galaxy
Wydad, Zamalek, Petro Atletico, Sagrada Esperança
By Mauwane Raophala